Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM449374
Substrate
n/a
Meas. Tech.
Enzymatic Reaction Assay
IC50
2.93±n/a nM
Citation
 Bair, KW; Baumeister, TR; Buckmelter, AJ; Clodfelter, KH; Dragovich, P; Gosselin, F; Gunzner-Toste, J; Han, B; Lin, J; Liu, X; Reynolds, DJ; Smith, CC; Wang, Z; Zak, M; Zhang, Y; Zhao, G; Zheng, X; Yuen, P Amido-benzyl sulfone and sulfoxide derivates US Patent  US10696692 Publication Date 6/30/2020 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM449374
Synonyms:
N-[[4-[[1-(2,2,2- tnfluoroethyl)-4- piperidyl]sulfinyl]phenyl] methyl]imidazo[1,2-a]pyridine- 6-carboxamide | US10696692, Example 364
Type:
Small organic molecule
Emp. Form.:
C22H23F3N4O2S
Mol. Mass.:
464.504
SMILES:
FC(F)(F)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Structure:
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