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Target
Mu-type opioid receptor
Ligand
BDBM449045
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2500±n/a nM
Citation
 Shoichet, BK; Lin, H; Gmeiner, P; Manglik, A; Kobilka, B; Roth, BL; Dengler, DG MU opioid receptor modulators US Patent  US10702498 Publication Date 7/7/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM449045
Synonyms:
US10702498, Compound 7 | US11484525, Compound 7
Type:
Small organic molecule
Emp. Form.:
C17H22ClN4O
Mol. Mass.:
333.835
SMILES:
C[NH+](C)[C@H](CNC(=O)Nc1cccnc1Cl)Cc1ccccc1 |r|
Structure:
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