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Target
Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM449875
Substrate
n/a
Meas. Tech.
Kinase Assay
EC50
10.8±n/a nM
Citation
 Larsen, J; Larsen, M; Rasmussen, LK; Ritzen, A; Duus, TM Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof US Patent  US10703751 Publication Date 7/7/2020 
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
Homo sapiens (Human)
Description:
P23458[850-1154]
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM449875
Synonyms:
US10703751, Example 1 | US10703751, Example 5 | trans-2-[4-[2-[1-Hydroxyethyl]-6-(methylamino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile
Type:
Small organic molecule
Emp. Form.:
C17H23N5O
Mol. Mass.:
313.3974
SMILES:
CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)C(C)O |r,wU:6.5,wD:9.9,(-2.58,-3.7,;-1.24,-4.47,;.09,-3.7,;.09,-2.16,;1.42,-1.39,;1.74,.12,;.66,1.2,;-.83,.81,;-1.92,1.89,;-1.52,3.38,;-2.61,4.47,;-4.1,4.07,;-5.59,3.67,;-.03,3.78,;1.05,2.69,;3.28,.28,;3.9,-1.13,;2.76,-2.16,;2.76,-3.7,;1.42,-4.47,;4.05,1.61,;3.28,2.94,;5.59,1.61,)|
Structure:
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