Target
Tyrosine-protein kinase JAK2
Ligand
BDBM449876
Substrate
n/a
Meas. Tech.
Kinase Assay
EC50
171±n/a nM
Citation
 Larsen, JLarsen, MRasmussen, LKRitzen, ADuus, TM Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof US Patent  US10703751 Publication Date 7/7/2020 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM449876
Synonyms:
US10703751, Example 2 | US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydroxyethyl]-6-(methylamino)imidazo[4,5-c]pyridin-1-yl]cyclo-hexyl]acetonitrile (Compound 2) and trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(methyl-amino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile
Type:
Small organic molecule
Emp. Form.:
C17H23N5O
Mol. Mass.:
313.3974
SMILES:
CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O |r,wU:6.5,20.24,wD:9.9,(1.71,-18.63,;3.03,-19.4,;4.36,-18.63,;4.36,-17.09,;5.69,-16.32,;6.01,-14.81,;4.98,-13.67,;3.48,-13.99,;2.45,-12.84,;2.92,-11.38,;1.89,-10.23,;.38,-10.55,;-1.12,-10.87,;4.43,-11.06,;5.46,-12.2,;7.54,-14.65,;8.17,-16.06,;7.03,-17.09,;7.03,-18.63,;5.69,-19.4,;8.31,-13.32,;7.54,-11.98,;9.85,-13.32,)|
Structure:
Search PDB for entries with ligand similarity: