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Target
N-formyl peptide receptor 2
Ligand
BDBM450358
Substrate
n/a
Meas. Tech.
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays
EC50
0.810±n/a nM
Citation
 Shirude, PS; Baligar, V; Seshadri, B; Chattopadhyay, AK; Wurtz, NR; Kick, EK Phenylpyrrolidinone formyl peptide 2 receptor agonists US Patent  US10676431 Publication Date 6/9/2020 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM450358
Synonyms:
US10676431, Example 121 | US10676431, Example 122 | US11117861, Example 122
Type:
Small organic molecule
Emp. Form.:
C25H23ClF3N4O3P
Mol. Mass.:
550.897
SMILES:
CC1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O |r|
Structure:
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