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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM397584
Substrate
n/a
Meas. Tech.
LSD1 histone demethylase biochemical assay
IC50
<100±n/a nM
Citation
 Wu, L; Yao, W Cyclopropylamines as LSD1 inhibitors US Patent  US10676457 Publication Date 6/9/2020 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM397584
Synonyms:
US10676457, Example 83 | US11155532, Example 83 | US9994546, Example 83 | [1-[(cis-4-hydroxycyclohexyl)carbonyl]-3-(4-{[(1R,2S)-2-phenylcyclopropyl]amino}piperidin-1-yl)azetidin-3-yl]acetonitrile
Type:
Small organic molecule
Emp. Form.:
C26H36N4O2
Mol. Mass.:
436.5896
SMILES:
O[C@H]1CC[C@H](CC1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1 |r,wU:23.25,4.7,1.0,(8.77,-5.22,;7.44,-4.45,;6.1,-5.22,;4.77,-4.45,;4.77,-2.91,;6.1,-2.14,;7.44,-2.91,;3.44,-2.14,;2.1,-2.91,;3.44,-.6,;2.35,.49,;3.44,1.58,;4.53,2.67,;6.01,2.27,;7.5,1.87,;4.53,.49,;2.1,2.35,;.77,1.58,;-.56,2.35,;-.56,3.89,;.77,4.66,;2.1,3.89,;-1.9,4.66,;-3.23,3.89,;-4,5.22,;-4.77,3.89,;-6.1,3.12,;-7.44,3.89,;-8.77,3.12,;-8.77,1.58,;-7.44,.81,;-6.1,1.58,)|
Structure:
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