Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM450616
Substrate
n/a
Meas. Tech.
Inositol Phosphate Turnover (IP1) Assay
EC50
0.200±n/a nM
Citation
 Miller, M; Chobanian, HR Antidiabetic bicyclic compounds US Patent  US10676458 Publication Date 6/9/2020 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM450616
Synonyms:
Sodium (2S,3R)-3-cyclopropyl-3-((R or S)-2-(2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydroquinolin-7-yl)-2-methylpropanoate (Example 11); and (2S,3R)-3-cyclopropyl-3-((S or R)-2-(2′-fluoro-5′-methoxy-[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydroquinolin-7-yl)-2-methylpropanoic acid (Example 12) | US10676458, Example 11 | US10676458, Example 12
Type:
Small organic molecule
Emp. Form.:
C29H29FNO3
Mol. Mass.:
458.5444
SMILES:
COc1ccc(F)c(c1)-c1ccc(cc1)C1CCc2ccc(cc2N1)[C@@H]([C@H](C)C([O-])=O)C1CC1 |r|
Structure:
Search PDB for entries with ligand similarity: