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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM450624
Substrate
n/a
Meas. Tech.
CHO GLP-1R Clone H6 Assay 1
EC50
880±n/a nM
Citation
 Aspnes, GE; Bagley, SW; Curto, JM; Edmonds, DJ; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Lian, Y; Limberakis, C; Londregan, AT; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent  US10676465 Publication Date 6/9/2020 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM450624
Synonyms:
2-({4-[2-(4-Chloro-2-fluorophenyl)-1,3-benzodioxol-4-yl]piperazin-1-yl}methyl)-1-(2-methoxyethyl)-1H-benzimidazole-6-carboxylic Acid, ENT-X1, Trifluoroacetate Salt (1) [from C39]; and 2-({4-[2-(4-Chloro-2-fluorophenyl)-1,3-benzodioxol-4-yl]piperazin-1-yl}methyl)-1-(2-methoxyethyl)-1H-benzimidazole-6-carboxylic Acid, ENT-X2, Trifluoroacetate Salt (2) [from C40] | US10676465, Example 1
Type:
Small organic molecule
Emp. Form.:
C30H30ClFN4O5
Mol. Mass.:
581.034
SMILES:
COCCn1c(CN2CCN(CC2)c2cccc3O[C@H](Oc23)c2ccc(Cl)cc2F)nc2ccc(cc12)C(=O)OC |r|
Structure:
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