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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM450637
Substrate
n/a
Meas. Tech.
CHO GLP-1R Clone C6 Assay 2
EC50
79.0±n/a nM
Citation
 Aspnes, GE; Bagley, SW; Curto, JM; Edmonds, DJ; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Lian, Y; Limberakis, C; Londregan, AT; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent  US10676465 Publication Date 6/9/2020 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM450637
Synonyms:
2-({4-[(2S)-2-(4-Chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]piperidin-1-yl}methyl)-1-methyl-1H-benzimidazole-6-carboxylic Acid | US10676465, Example 14
Type:
Small organic molecule
Emp. Form.:
C29H27ClFN3O4
Mol. Mass.:
535.994
SMILES:
Cn1c(CN2CCC(CC2)c2cccc3O[C@@](C)(Oc23)c2ccc(Cl)cc2F)nc2ccc(cc12)C(O)=O |r|
Structure:
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