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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM450656
Substrate
n/a
Meas. Tech.
CHO GLP-1R Clone H6 Assay 1
EC50
2.60±n/a nM
Citation
 Aspnes, GE; Bagley, SW; Curto, JM; Edmonds, DJ; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Lian, Y; Limberakis, C; Londregan, AT; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent  US10676465 Publication Date 6/9/2020 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM450656
Synonyms:
2-({4-[2-(4-chlorophenyl)-2-methyl-1,3- benzodioxol-4-yl]piperidin-1-yl}methyl)-1- (2-methoxyethyl)-1H-benzimidazole-6- carboxylic acid, formate salt | US10676465, Example 33
Type:
Small organic molecule
Emp. Form.:
C31H32ClN3O5
Mol. Mass.:
562.056
SMILES:
COCCn1c(CN2CCC(CC2)c2cccc3OC(C)(Oc23)c2ccc(Cl)cc2)nc2ccc(cc12)C(O)=O
Structure:
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