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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM450674
Substrate
n/a
Meas. Tech.
CHO GLP-1R Clone C6 Assay 2
EC50
280±n/a nM
Citation
 Aspnes, GE; Bagley, SW; Curto, JM; Edmonds, DJ; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Lian, Y; Limberakis, C; Londregan, AT; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent  US10676465 Publication Date 6/9/2020 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM450674
Synonyms:
2-({4-[2-(4-chloro-2-fluorophenyl)-2- methyl-1,3-benzodioxol-4-yl]piperidin-1- yl}methyl)-1-[(1-ethyl-1H-imidazol-2- yl)methyl]-1H-benzimidazole-6- carboxylic acid | US10676465, Example 51
Type:
Small organic molecule
Emp. Form.:
C34H33ClFN5O4
Mol. Mass.:
630.108
SMILES:
CCn1ccnc1Cn1c(CN2CCC(CC2)c2cccc3OC(C)(Oc23)c2ccc(Cl)cc2F)nc2ccc(cc12)C(O)=O
Structure:
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