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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM450720
Substrate
n/a
Meas. Tech.
CHO GLP-1R Clone H6 Assay 1
EC50
1.10±n/a nM
Citation
 Aspnes, GE; Bagley, SW; Curto, JM; Edmonds, DJ; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Lian, Y; Limberakis, C; Londregan, AT; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent  US10676465 Publication Date 6/9/2020 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM450720
Synonyms:
2-({4-[2-(4-chloro-2-fluorophenyl)-7- fluoro-2-methyl-1,3-benzodioxol-4- yl]piperidin-1-yl}methyl)-1-[(2S)-oxetan- 2-ylmethyl]-1H-benzimidazole-6- carboxylic acid, DIAST-1 [footnote 10 in Table 2] | US10676465, Example 96 | US10676465, Example 97
Type:
Small organic molecule
Emp. Form.:
C32H30ClF2N3O5
Mol. Mass.:
610.048
SMILES:
CC1(Oc2c(O1)c(ccc2F)C1CCN(Cc2nc3ccc(cc3n2C[C@@H]2CCO2)C(O)=O)CC1)c1ccc(Cl)cc1F |r|
Structure:
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