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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM450762
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay
IC50
76.4±21.6 nM
Citation
 Tu, Z; Rosenberg, A; Liu, H; Han, J Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof US Patent  US10676467 Publication Date 6/9/2020 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM450762
Synonyms:
US10676467, Compound TZ 35 139
Type:
Small organic molecule
Emp. Form.:
C26H21F4N3O4
Mol. Mass.:
515.4563
SMILES:
OC(=O)C1CN(Cc2ccc3oc(nc3c2)-c2ccc(-c3ccc(OCCF)nc3)c(c2)C(F)(F)F)C1
Structure:
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