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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM451153
Substrate
n/a
Meas. Tech.
kinetic binding analysis
Ki
4900±n/a nM
Citation
 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F 3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA US Patent  US10676499 Publication Date 6/9/2020 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM451153
Synonyms:
US10676499, Example 42
Type:
Small organic molecule
Emp. Form.:
C24H25N6O11PS
Mol. Mass.:
636.528
SMILES:
COC(=O)c1ccsc1NC(=O)c1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1 |r|
Structure:
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