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Target
Ubiquitin-like modifier-activating enzyme 6
Ligand
BDBM299265
Substrate
n/a
Meas. Tech.
UBA6 AlphaScreen Assay
IC50
1025±n/a nM
Citation
 Amidon, BS; Cardin, DP; Gould, AE; Greenspan, PD; Harrison, SJ Indole substituted pyrrolopyrimidinyl inhibitors of Uba6 US Patent  US9593121 Publication Date 3/14/2017 
Target
Name:
Ubiquitin-like modifier-activating enzyme 6
Synonyms:
E1-L2 | MOP-4 | MOP4 | Monocyte protein 4 | UBA6 | UBA6_HUMAN | UBE1L2 | Ubiquitin-activating enzyme 6 | Ubiquitin-activating enzyme E1-like protein 2
Type:
PROTEIN
Mol. Mass.:
117960.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939704
Residue:
1052
Sequence:
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATSISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKKYVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD
  
Inhibitor
Name:
BDBM299265
Synonyms:
US9593121, I-10 | tert-butyl 2-(7-{(1R,3S,4S)-3-hydroxy-4- [(sulfamoyloxy)methyl]cyclopentyl}-7H-pyrrolo[2,3- d]pyrimidin-4-yl)-6-methoxy-1H-indole-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H31N5O7S
Mol. Mass.:
557.619
SMILES:
COc1ccc2cc(-c3ncnc4n(ccc34)[C@H]3C[C@H](O)[C@H](COS(N)(=O)=O)C3)n(C(=O)OC(C)(C)C)c2c1
Structure:
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