Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM300157
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
2.30±n/a nM
Citation
 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A Triazolo[4,5-D]pyrimidine derivatives US Patent  US9593123 Publication Date 3/14/2017 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM300157
Synonyms:
(3S)-1-[5-(tert-Butylamino)-3-[(2-chlorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol | US9593123, Example 28
Type:
Small organic molecule
Emp. Form.:
C19H24ClN7O
Mol. Mass.:
401.893
SMILES:
CC(C)(C)Nc1nc(N2CC[C@H](O)C2)c2nnn(Cc3ccccc3Cl)c2n1 |r|
Structure:
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