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Target
Methionine aminopeptidase 2
Ligand
BDBM468981
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay of MetAP2
IC50
283±58 nM
Citation
 Ho, KK; Quan, W; Zhou, J Pyrrolidinone compounds US Patent  US10807971 Publication Date 10/20/2020 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
MAP2_MOUSE | Metap2 | Methionine aminopeptidase Type 2 (MetAP2) | Mnpep | P67eif2 | Peptidase M 2
Type:
Enzyme
Mol. Mass.:
52914.64
Organism:
Mus musculus (Mouse)
Description:
O08663
Residue:
478
Sequence:
MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM468981
Synonyms:
(3S)-1-[2-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)tetrahydropyran-3-yl]-3,6-dihydro-2H-pyridin-4-yl]pyrimidin-5-yl]-N-[(3-chloro-5-fluoro-phenyl)methyl]-3-hydroxy-2-oxo-pyrrolidine-3-carboxamide, hydrochloride | US10807971, Example 17
Type:
Small organic molecule
Emp. Form.:
C32H32ClF3N6O4
Mol. Mass.:
657.082
SMILES:
N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1CCC(=CC1)c1ncc(cn1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r,c:20|
Structure:
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