Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM168431
Substrate
n/a
Meas. Tech.
IDO Kynurenine Assay
Temperature
298.15±n/a K
EC50
994±n/a nM
Comments
extracted
Citation
 PubChem, PC; Balog, JA; Huang, A; Chen, B; Chen, L; Seitz, SP; Hart, AC; Markwalder, JA Inhibitors of indoleamine 2,3-dioxygenase (IDO) US Patent  US9675571 Publication Date 6/13/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM168431
Synonyms:
US9675571, 87
Type:
Small organic molecule
Emp. Form.:
C24H28F3N5O3
Mol. Mass.:
491.506
SMILES:
OC(=O)[C@@H]1C[C@@H]1c1ccc(N(CCC(F)(F)F)C2CCCCC2)c(NC(=O)Nc2cncnc2)c1 |r|
Structure:
Search PDB for entries with ligand similarity: