Target
NADPH oxidase 1
Ligand
BDBM300385
Substrate
n/a
Meas. Tech.
ROS Production Measurement on hNOX1 Membranes
Ki
74.0±n/a nM
Citation
 Machin, PSharpe, ALock, CJChambers, MSHodges, AAllen, VEllard, JM Amido thiadiazole derivatives as NADPH oxidase inhibitors US Patent  US10130619 Publication Date 11/20/2018 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM300385
Synonyms:
US10130619, Example 86
Type:
Small organic molecule
Emp. Form.:
C25H24N4O4S
Mol. Mass.:
476.547
SMILES:
COCCOc1cc(ccc1OC(C)c1ccccc1)C(=O)Nc1nnc(s1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: