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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM347365
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
1.41±n/a nM
Citation
 Markowitz, S; Wilson, JK; Posner, B; Ready, J; Antczak, M; Zhang, Y; Desai, A; Gerson, S; Greenlee, W; Yeun Yang, S; Bae, K Compositions and methods of modulating short-chain dehydrogenase activity US Patent  US10869871 Publication Date 12/22/2020
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM347365
Synonyms:
US10301320, ID SW206992 | US10869871, ID # SW206992 | US20230285402, ID # SW206992 | US9789116, SW206992
Type:
Small organic molecule
Emp. Form.:
C14H15N3OS3
Mol. Mass.:
337.483
SMILES:
CCCCS(=O)c1sc2nc(ccc2c1N)-c1nccs1
Structure:
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