Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM347405
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
1.83±n/a nM
Citation
 Markowitz, SWilson, JKPosner, BReady, JAntczak, MZhang, YDesai, AGerson, SGreenlee, WYeun Yang, SBae, K Compositions and methods of modulating short-chain dehydrogenase activity US Patent  US10869871 Publication Date 12/22/2020 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM347405
Synonyms:
US10869871, ID # SW209124 | US20230285402, ID # SW209124 | US9789116, SW209124
Type:
Small organic molecule
Emp. Form.:
C17H16N4OS4
Mol. Mass.:
420.595
SMILES:
CCCCS(=O)c1sc2nc(cc(-c3nccs3)c2c1N)-c1nccs1
Structure:
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