Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300819
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
6.00±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300819
Synonyms:
(3S)-3-(4-((3-(4-((1,1- Dioxidotetrahydro-2H- thiopyran-4-yl)methoxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl) hex-4-ynoic acid | US10131648, Compound 17 | US10195178, Compound 17 | US9790198, Compound 17
Type:
Small organic molecule
Emp. Form.:
C34H34O6S2
Mol. Mass.:
602.76
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5CCS(=O)(=O)CC5)cc4C)c3c2)cc1 |r|
Structure:
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