Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300856
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
44.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300856
Synonyms:
(3S)-3-[4-[([3-[4-(3-Hydroxy-3- methylbutoxy)-2- methylphenyl]-1- benzothiophen-5- yl]oxy)methyl]phenyl] hex-4-ynoic acid | US10131648, Compound 54 | US10195178, Compound 54 | US9790198, Compound 54
Type:
Small organic molecule
Emp. Form.:
C33H34O5S
Mol. Mass.:
542.685
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(COc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1 |r|
Structure:
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