Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300901
Substrate
n/a
Meas. Tech.
Inositol Phosphate Turnover (IP1) Assay
EC50
14.0±n/a nM
Citation
 Chobanian, H; DeMong, D; Plummer, CW; Fang, M; Hu, B [7,6]-fused bicyclic antidiabetic compounds US Patent  US10131651 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300901
Synonyms:
(2S,3R)-3-cyclopropyl-3-((R or S)-2-(2-fluoro-4-(2-methoxypyridin-4-yl)phenyl)-2,3,4,5-tetrahydrobenzo[b]oxepin-8-yl)-2-methylpropanoic acid | BDBM300902 | US10131651, Example 1
Type:
Small organic molecule
Emp. Form.:
C29H30FNO4
Mol. Mass.:
475.5512
SMILES:
COc1cc(ccn1)-c1ccc(C2CCCc3ccc(cc3O2)[C@@H]([C@H](C)C(O)=O)C2CC2)c(F)c1 |r|
Structure:
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