Reaction Details Report a problem with these data
Target
Endothelin-1
Ligand
BDBM168542
Substrate
n/a
Meas. Tech.
ET-1 Assay
EC50
>200000±n/a nM
Citation
 PubChem, PC; Buckman, BO; Nicholas, JB; Ramphal, JY; Emayan, K; Seiwert, SD Anti-fibrotic pyridinones US Patent  US9675593 Publication Date 6/13/2017 
Target
Name:
Endothelin-1
Synonyms:
EDN1 | EDN1_HUMAN | PPET1 | Preproendothelin-1
Type:
Protein
Mol. Mass.:
24444.51
Organism:
Homo sapiens (Human)
Description:
P05305
Residue:
212
Sequence:
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW
  
Inhibitor
Name:
BDBM168542
Synonyms:
US9675593, 97
Type:
Small organic molecule
Emp. Form.:
C24H20F4N2O4
Mol. Mass.:
476.4202
SMILES:
Fc1ccc(cc1)-c1cn(-c2ccc(OC(F)(F)F)cc2)c(=O)cc1OCCN1CCCC1=O
Structure:
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