Target

Ligand

Substrate

Meas. Tech.

Kinase Inhibition SPA Assay

Citation

 Bramson, HN; Corona, J; Davis, ST; Dickerson, SH; Edelstein, M; Frye, SV; Gampe, RT; Harris, PA; Hassell, A; Holmes, WD; Hunter, RN; Lackey, KE; Lovejoy, B; Luzzio, MJ; Montana, V; Rocque, WJ; Rusnak, D; Shewchuk, L; Veal, JM; Walker, DH; Kuyper, LF Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis. J Med Chem 44:4339-58 (2001) [PubMed]  Article Copy BDB DOI

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Name:

Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1

Synonyms:

CDK1/B | CDK1/Cyclin B | CDK1/CyclinB | Cyclin B/Dependent Kinase 1 (CDK1) | Cyclin-Dependent Kinase 1 (CDK1) | Cyclin-dependent kinase 1/cyclin B1 | Cyclin-dependent kinase/G2/mitotic-specific cyclin 1 | cdk1

Type:

Protein Complex

Mol. Mass.:

n/a

Description:

CDK1/Cyclin B complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components.

Components:

This complex has 2 components.

Name:

Cyclin-dependent kinase 1

Synonyms:

CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase

Type:

Enzyme Subunit

Mol. Mass.:

34101.08

Organism:

Homo sapiens (Human)

Description:

P06493

Residue:

297

Sequence:

MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM

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Name:

G2/mitotic-specific cyclin-B1

Synonyms:

CCNB | CCNB1 | CCNB1_HUMAN

Type:

Enzyme Subunit

Mol. Mass.:

48340.95

Organism:

Homo sapiens (Human)

Description:

P14635

Residue:

433

Sequence:

MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV

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Name:

BDBM7770

Synonyms:

N-(2-Hydroxyethyl)(4-{[(7-oxo-6,7-dihydro-8H-[1,3]-thiazolo[5,4-e]indol-8-ylidene)methyl]amino}phenyl)-methanesulfonamide | N-(2-hydroxyethyl)[4-({[(12Z)-11-oxo-3-thia-5,10-diazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8-tetraen-12-ylidene]methyl}amino)phenyl]methanesulfonamide | Oxindole-Based Inhibitor 106

Type:

Small organic molecule

Emp. Form.:

C19H18N4O4S2

Mol. Mass.:

430.501

SMILES:

OCCNS(=O)(=O)Cc1ccc(cc1)N=CC1C(=O)Nc2ccc3ncsc3c12 |w:15.16|

Structure:

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Name:

Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

5198.94

Organism:

n/a

Description:

n/a

Residue:

46

Sequence:

ITINAMINHEYLALAARGARGPRMETSERPRLYSLYSLYSALACNH