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TargetGlycogen synthase kinase-3 beta
LigandBDBM484629
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
EC50 5.00±n/a nM
Citation Kc, SKMak, CCMittapalli, GKHofilena, BJEastman, BWCao, JChiruta, CBollu, V 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof US Patent US10934297 Publication Date 3/2/2021
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM484629
NameBDBM484629
Synonyms:US10934297, Compound 23
TypeSmall organic molecule
Emp. Form.C22H27FN6O
Mol. Mass.410.4878
SMILESCn1cc(cn1)-c1ccc2[nH]nc(C(=O)N[C@H]3CC[C@H](CN4CC(F)C4)CC3)c2c1 |r,wU:19.20,wD:16.16,(-7.69,.41,;-7.29,-1.08,;-5.83,-1.56,;-5.83,-3.1,;-7.29,-3.57,;-8.2,-2.33,;-4.49,-3.87,;-4.49,-5.41,;-3.16,-6.18,;-1.83,-5.41,;-.36,-5.88,;.54,-4.64,;-.36,-3.39,;.04,-1.9,;-1.05,-.81,;1.52,-1.51,;1.92,-.02,;3.41,.38,;3.81,1.87,;2.72,2.96,;3.12,4.44,;4.61,4.84,;5.94,4.07,;6.71,5.41,;8.2,5.81,;5.38,6.18,;1.23,2.56,;.83,1.07,;-1.83,-3.87,;-3.16,-3.1,)|
Structure
n/a