Reaction Details Report a problem with these data
Target
Protein M2-1
Ligand
BDBM301503
Substrate
n/a
Meas. Tech.
Antiviral Activity
EC50
282±n/a nM
Citation
 Tahari, A; Vendeville, SM; Jonckers, TH; Raboisson, PJ; Demin, SD; Hu, L Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV) US Patent  US10131673 Publication Date 11/20/2018 
Target
Name:
Protein M2-1
Synonyms:
Envelope-associated 22 kDa protein | M2-1 | M21_HRSVA | Matrix M2-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22163.59
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
P04545
Residue:
194
Sequence:
MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT
  
Inhibitor
Name:
BDBM301503
Synonyms:
2-(1-(5-methylquinazolin-4-yl)piperidin-2-yl)-9-morpholino-6,8-dihydro-5H-pyrano[4,3-d]pyrazolo[1,5-a]pyrimidine | US10131673, Compound P30
Type:
Small organic molecule
Emp. Form.:
C27H31N7O2
Mol. Mass.:
485.5807
SMILES:
Cc1cccc2ncnc(N3CCCCC3c3cc4nc5CCOCc5c(N5CCOCC5)n4n3)c12
Structure:
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