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Target
Mitogen-activated protein kinase kinase kinase 12
Ligand
BDBM301549
Substrate
n/a
Meas. Tech.
DLK TR-FRET Inhibition Assay
Ki
235±n/a nM
Citation
 Estrada, A; Patel, S; Kellar, T; Huestis, M; Shore, D; Siu, M Tricyclic DLK inhibitors and uses thereof US Patent  US10131675 Publication Date 11/20/2018 
Target
Name:
Mitogen-activated protein kinase kinase kinase 12
Synonyms:
DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK
Type:
PROTEIN
Mol. Mass.:
93216.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1460553
Residue:
859
Sequence:
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
  
Inhibitor
Name:
BDBM301549
Synonyms:
US10131675, Example 35
Type:
Small organic molecule
Emp. Form.:
C20H22ClN7O
Mol. Mass.:
411.888
SMILES:
CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(Cl)c1)N1CC2CC1C2 |(6.82,3.22,;5.33,2.82,;6.1,1.48,;5.17,4.35,;3.77,4.98,;2.52,4.07,;2.68,2.54,;4.09,1.91,;3.93,.38,;2.42,.06,;1.65,-1.27,;.11,-1.27,;-.66,.06,;.11,1.39,;1.65,1.39,;-2.2,.06,;-2.97,-1.27,;-4.51,-1.27,;-5.28,.06,;-6.82,.06,;-4.51,1.39,;-5.28,2.73,;-2.97,1.39,;2.42,-2.61,;3.96,-2.61,;4.44,-4.07,;3.19,-4.98,;1.94,-4.07,;3.16,-3.7,)|
Structure:
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