Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM301739
Substrate
n/a
Meas. Tech.
Pharmacological Assay
EC50
12.0±n/a nM
Citation
 Eckhardt, M; Frattini, S; Langkopf, E; Wagner, H Indanyloxydihydrobenzofuranylacetic acids US Patent  US9597310 Publication Date 3/21/2017 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM301739
Synonyms:
US9597310, 29 | {(S)-6-[(R)-7-Fluoro-4-{5-[(S)-tetrahydro-furan-3-yloxy}-pyridin-2-yloxy}-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C29H28FNO7
Mol. Mass.:
521.5335
SMILES:
COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(O[C@H]4CCOC4)cn3)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: