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Target
N-lysine methyltransferase SMYD2
Ligand
BDBM301811
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
32800±n/a nM
Citation
 Chiang, GG; Pappano, WN; Sweis, RF; Wang, Z SMYD2 inhibitors US Patent  US9598381 Publication Date 3/21/2017 
Target
Name:
N-lysine methyltransferase SMYD2
Synonyms:
HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN
Type:
Enzyme
Mol. Mass.:
49689.57
Organism:
Homo sapiens (Human)
Description:
Q9NRG4
Residue:
433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
  
Inhibitor
Name:
BDBM301811
Synonyms:
N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((6-methyl-3-neopentyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-2-yl)-amino)ethyl)-propanamide | US9598381, 8
Type:
Small organic molecule
Emp. Form.:
C31H48Cl2N6O
Mol. Mass.:
591.658
SMILES:
CC1CNc2c(CC(C)(C)C)c(NCCN(C3CCCCC3)C(=O)CCNCCc3ccc(Cl)c(Cl)c3)nn2C1
Structure:
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