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Target
N-lysine methyltransferase SMYD2
Ligand
BDBM301812
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
>50000±n/a nM
Citation
 Chiang, GG; Pappano, WN; Sweis, RF; Wang, Z SMYD2 inhibitors US Patent  US9598381 Publication Date 3/21/2017 
Target
Name:
N-lysine methyltransferase SMYD2
Synonyms:
HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN
Type:
Enzyme
Mol. Mass.:
49689.57
Organism:
Homo sapiens (Human)
Description:
Q9NRG4
Residue:
433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
  
Inhibitor
Name:
BDBM301812
Synonyms:
(S)-N-cyclohexyl-3-(phenethylamino)-N-(2-(2-((pyridin-3-yloxy)methyl)azetidin-1-yl)ethyl)propanamide | US9598381, 9
Type:
Small organic molecule
Emp. Form.:
C28H40N4O2
Mol. Mass.:
464.6428
SMILES:
O=C(CCNCCc1ccccc1)N(CCN1CC[C@H]1COc1cccnc1)C1CCCCC1
Structure:
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