Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM301989
Substrate
n/a
Meas. Tech.
Binding Affinity Human 5-HT1A Receptor Test
Ki
14.0±n/a nM
Citation
 Zhang, Y; Jin, C; Zhou, R Substituted heteroaryl compounds and methods of use thereof US Patent  US9598401 Publication Date 3/21/2017 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM301989
Synonyms:
2-(4-(4-(5-Fluoro-1H-indol-3-yl)butyl)piperazin-1-yl)-4-methylthiazole-5-carbonitrile | US9598401, Example 45
Type:
Small organic molecule
Emp. Form.:
C21H24FN5S
Mol. Mass.:
397.512
SMILES:
Cc1nc(sc1C#N)N1CCN(CCCCc2c[nH]c3ccc(F)cc23)CC1
Structure:
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