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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7911
Substrate
BDBM7883
Meas. Tech.
QC Inhibition Testing
Ki
1860±n/a nM
Citation
 Buchholz, M; Heiser, U; Schilling, S; Niestroj, AJ; Zunkel, K; Demuth, HU The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem 49:664-77 (2006) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM7911
Synonyms:
1-(3-(1H-Imidazol-1-yl)propyl)-3-(3-methoxyphenyl)thiourea | 1-alkylimidazole thiourea deriv. 46 | 3-[3-(1H-imidazol-1-yl)propyl]-1-(3-methoxyphenyl)thiourea
Type:
Small organic molecule
Emp. Form.:
C14H18N4OS
Mol. Mass.:
290.384
SMILES:
COc1cccc(NC(=S)NCCCn2ccnc2)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM7883
Synonyms:
(2S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanediamide | Gln-AMC | L-glutaminyl-4-methylcoumarinylamide
Type:
Small organic molecule
Emp. Form.:
C15H17N3O4
Mol. Mass.:
303.3132
SMILES:
Cc1cc(=O)oc2cc(NC(=O)[C@@H](N)CCC(N)=O)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: