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Target
Tyrosine-protein kinase SYK
Ligand
BDBM302011
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
IC50
1.84±n/a nM
Citation
 Altman, MD; Andresen, BM; Arrington, KL; Childers, KK; Di Francesco, ME; Ellis, JM; Haidle, AM; Liu, Y; Northrup, AB; O Boyle, B; Otte, RD; Reutershan, MH; Vitharana, D; Woo, HC Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors US Patent  US9598405 Publication Date 3/21/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM302011
Synonyms:
US9598405, 2.10
Type:
Small Organic Molecule
Emp. Form.:
C25H28N4O5S
Mol. Mass.:
496.579
SMILES:
CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C(=O)OC)n1 |(-7.3,.16,;-5.76,.1,;-5.04,-1.26,;-3.5,-1.31,;-2.69,-0,;-2.78,-2.67,;-1.24,-2.72,;-.52,-4.08,;-1.33,-5.39,;-.06,-6.25,;-2.87,-5.34,;-3.6,-3.98,;-1.33,-6.93,;-2.58,-7.84,;-2.1,-9.3,;-.56,-9.3,;-.09,-7.84,;.34,-10.55,;1.87,-10.38,;2.78,-11.63,;4.31,-11.47,;2.15,-13.04,;.62,-13.2,;-.01,-14.61,;.9,-15.85,;.27,-17.26,;1.18,-18.5,;2.71,-18.34,;3.34,-16.94,;2.43,-15.69,;.55,-19.91,;-.98,-20.07,;1.46,-21.16,;2.99,-21,;-.28,-11.95,)|
Structure:
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