Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7949
Substrate
BDBM7883
Meas. Tech.
QC Inhibition Testing
pH
8±n/a
Temperature
303.15±n/a K
Ki
17000±1000 nM
Citation
 Schilling, SNiestroj, AJRahfeld, JUHoffmann, TWermann, MZunkel, KWasternack, CDemuth, HU Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. J Biol Chem 278:49773-9 (2003) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM7949
Synonyms:
Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl)ethyl]acetamide | N-omega-Acetylhistamine | N-w-acetylhistamine (AH)
Type:
Small organic molecule
Emp. Form.:
C7H11N3O
Mol. Mass.:
153.1817
SMILES:
CC(=O)NCCc1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM7883
Synonyms:
(2S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanediamide | Gln-AMC | L-glutaminyl-4-methylcoumarinylamide
Type:
Small organic molecule
Emp. Form.:
C15H17N3O4
Mol. Mass.:
303.3132
SMILES:
Cc1cc(=O)oc2cc(NC(=O)[C@@H](N)CCC(N)=O)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: