Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7949
Substrate
BDBM7883
Meas. Tech.
QC Inhibition Testing
pH
8±n/a
Temperature
303.15±n/a K
Ki
17000±1000 nM
Citation
Schilling, S; Niestroj, AJ; Rahfeld, JU; Hoffmann, T; Wermann, M; Zunkel, K; Wasternack, C; Demuth, HU Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. J Biol Chem 278:49773-9 (2003) [PubMed] Article
More Info.:
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
Inhibitor
Name:
BDBM7949
Synonyms:
Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl)ethyl]acetamide | N-omega-Acetylhistamine | N-w-acetylhistamine (AH)
Type:
Small organic molecule
Emp. Form.:
C7H11N3O
Mol. Mass.:
153.1817
SMILES:
CC(=O)NCCc1cnc[nH]1