Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 3
Ligand
BDBM179706
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
890±n/a nM
Citation
 Bialy, L; Lorenz, K; Wirth, K; Steinmeyer, K; Hessler, G; Pernerstorfer, J; Brendel, J Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them US Patent  US9598410 Publication Date 3/21/2017 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
Protein
Mol. Mass.:
43534.71
Organism:
Homo sapiens (Human)
Description:
O14649
Residue:
394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
  
Inhibitor
Name:
BDBM179706
Synonyms:
US9127001, 8m | US9598410, Compound 8m
Type:
Small organic molecule
Emp. Form.:
C25H22F2N4O2
Mol. Mass.:
448.4646
SMILES:
Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCOC2)-c2cccc(c2)C#N)c(F)c1
Structure:
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