| Assay Method Information | |
| | SMAD Transcription Factor Inhibitors Dose Response Confirmation |
| Description: | NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: F.M. Hoffmann, University of Wisconsin-Madison MLSCN Grant: 1R21NS057002-01 Assay Overview: Transforming growth factor beta (TGF-Beta) regulates a variety of processes in mammalian cells, including proliferation, apoptosis, cell migration and extracellular matrix production. Aberrant increases in TGF-Beta signaling have been implicated in several pathological conditions including cancer and fibrosis. Inhibition of TGF-Beta signaling is an important tool in elucidating the multiple biological functions of TGF-Beta and is of significant interest as a potential therapeutic strategy in fibrotic diseases and several advanced cancers. Smad proteins mediate cellular responses to TGF-Beta. TGF-Beta alters cellular gene expression and cell behavior by binding and activating the Type II and Type I serine kinase receptors on the cell membrane. Activated Type I recep |
| Affinity data for this assay | |
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