| Assay Method Information | |
| | S1P3 Dose Response Assay Counterscreen for 5-Hydroxytryptamine(Serotonin) Receptor Subtype 1E Antagonists |
| Description: | External Assay ID: S1P3_IC50_CS_5H1E_Antagonists Name: S1P3 Dose Response Assay Counterscreen for 5-Hydroxytryptamine(Serotonin) Receptor Subtype 1E Antagonists Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: The Scripps Research Institute Molecular Screening Center Network: Molecular Library Screening Center Network (MLSCN) Grant Proposal Number: 1 R03 MH076345-01 Description: The neurotransmitter, serotonin (5HT, 5-hydroxytryptamine) is important in a large number of neurological behaviors including of mood [1], appetite [2], cognition [3], pain [4], and memory [5]. The serotonin receptors are a large group of GPCRs which are divided into families, 5HT1-7, based upon functionality and pharmacology [6]. The 5HT1 family which includes at least 6 members, 5HT1A-F, is indicated in anxiety, depression and cognition [7]. All of the 5HT1 receptors activate gi/o g-proteins to inhi |
| Affinity data for this assay | |
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