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Assay Method Information

Assay Name:  Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Stefan Heller, Stanford University Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number 1 R03 MH083077-01 Grant Proposal PI: Stefan Heller , Stanford University External Assay ID: TRPML3_AG_Calcium_1536_EC50 Name: Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) Description: Cell signaling pathways that mediate osmosensation, photosensation, and thermosensation depend on a family of diverse transient receptor potential (TRP) cation channels, which are activated by agonist-receptor coupling (1-5). A role for these channels in inner ear hair cell mechanotransduction was gleaned from TRP channel mutations identified in flies, worms, and lower vertebrates with defective balance and impaired sensitivity to
Affinity data for this assay
 

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Last update November 1, 2007
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