| Assay Method Information | |
| | TRFRET-based cell-based high throughput dose response assay for biased ligands (antagonists) of the melanocortin 4 receptor (MC4R) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Scott DeWire, Trevena Inc Network: Molecular Library Probe Production Center Network (MLPCN) Grant Proposal Number: 1 RC2 MH090877-01 Grant Proposal PI: Scott DeWire, Trevena Inc External Assay ID: MC4R_ANT_TRFRET_1536_3XIC50 DRUN Name: TRFRET-based cell-based high throughput dose response assay for biased ligands (antagonists) of the melanocortin 4 receptor (MC4R). Description: Heterotrimeric G-protein coupled receptors (GPCRs) are major targets for disease therapeutics, due in part to their broad tissue distribution, structural diversity, varied modes of action, and disease-associated mutations (1-4). However, it has recently been demonstrated that GPCRs do not only signal in this simplistic fashion, but rather activate a network of downstream effects comprised of parallel signal transduction pathways. GPCR ligands |
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