Assay Method Information

Assay Name:  Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Joel Buxbaum, The Scripps Research Institute (TSRI) Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: R21AG041496 Grant Proposal PI: Joel Buxbaum, The Scripps Research Institute (TSRI) External Assay ID: TTR-HUH7_INH_LUMI_1536_3XIC50 DCSRUN Name: Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells. Description: The "Amyloid Hypothesis" of human Alzheimer's disease (AD) is based on human genetic data, murine models in which mutant human Amyloid-B Precursor Protein (ABPP) and/or presenilins are expressed, and in vitro and tissue culture evidence indicating that aggregation of various forms of the neuronal ABPP cleavage p
Affinity data for this assay
 

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