Assay Method Information

Assay Name:  JAK2 (PSTAT5 UT7) Alpha Screen Assay
Description:  Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhibition of EPO induced phosphorylation of STATS in UT7 cells. From these tests, the EC50 (effective concentration for 50% maximal response) values were determined in 1 μM for the test compounds.
Affinity data for this assay
 

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