Substrate: polymer

Details for Substrate Dual specificity mitogen-activated protein kinase kinase 1 [K97R] without Explicit Binding Affinity Data

Binding Enzyme 1:

RAF proto-oncogene serine/threonine-protein kinase

Binding Enzyme 2:

Serine/threonine-protein kinase B-raf [V600E]

Binding Enzyme 3:

RAF proto-oncogene serine/threonine-protein kinase [1-324]

Binding Enzyme 4:

RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]

Synonyms:

Type:

n/a

Topology:

n/a

Mol. Mass.:

43467.04 Dalton

Organism:

Homo sapiens (Human)

Description:

Biotinylated full length MEK1 with an inactivating K97R ATP binding site mutation.

Residue:

393

Sequence:

MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARRLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV