Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 4DJH Sort by
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0100nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0200nMAssay Description:Antagonist activity at kappa opioid receptor in guinea pig caudate assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0300nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0591nMAssay Description:Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.320nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Rat)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]U69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity of compound for Opioid receptor kappa 1 was determined using [3H]U-69593 as radioligand from guinea pig caudateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)