45 articles for thisTarget
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Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir.
Sankyo
Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir.
Sankyo
Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives.
Sankyo
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity.
University of Alabama At Birmingham
Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.
Miyagi Cancer Center Research Institute
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
Biocryst Pharmaceuticals
Binding constants of neuraminidase inhibitors: An investigation of the linear interaction energy method.
University of Southampton
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Glaxo Wellcome Research and Development
Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis.
Monash University
Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.
Glaxowellcome Medicines Research Centre
Novel inhibitors of influenza sialidases related to zanamivir. Heterocyclic replacements of the glycerol sidechain
TBA
Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides
TBA
Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase
TBA
Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors.
Saitama University
3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase.
Chinese Academy of Medical Sciences
Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai.
University of Innsbruck
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors
Shandong University
Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.
Glaxosmithkline
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.
Abbott Laboratories
Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase.
Shenyang Pharmaceutical University
Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.
Abbott Laboratories
Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents.
Prin. K.M. Kundnani College of Pharmacy
Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity.
National Taiwan University
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.
Shandong University
Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.
University of Alabama At Birmingham
Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases.
Chinese Academy of Sciences
Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors.
Shandong University
Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.
Charles University
Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.
Shanghai Institute of Technology
Design, synthesis and biological evaluation of oseltamivir derivatives containing pyridyl group as potent inhibitors of neuraminidase for influenza A.
Wuyi University
Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity.
Ocean University of China
QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors.
Universidad De Buenos Aires
Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates.
Meiji Pharmaceutical University
Discovery of berberine based derivatives as anti-influenza agent through blocking of neuraminidase.
Konkuk University
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Shandong University
C-Methylated Flavonoid Glycosides from Pentarhizidium orientale Rhizomes and Their Inhibitory Effects on the H1N1 Influenza Virus.
Seoul National University
Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).
Boehringer Ingelheim Pharmaceuticals
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
Boehringer Ingelheim Pharmaceuticals
1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
Abbott Laboratories
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.
Wyeth Research