52 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors.
E£Tv£S Lor£Nd University (Elte)
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.
University of Florida
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
Kyung Hee University
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.
Ewha Womans University
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Shenyang Pharmaceutical University
D-amino acid containing, high-affinity inhibitors of recombinant human calpain I.
Cephalon
Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.
Maxim Pharmaceuticals
1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors.
Cephalon
Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.
Hoechst Marion Roussel
Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors.
College of Pharmacy Kyung Hee University
Molecular design to enhance the penetration into the retina via ocular instillation.
Senju Pharmaceutical
Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors.
Kyung Hee University
Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives.
Senju Pharmaceutical
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.
The University of Arizona
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.
Niddk
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors.
Institute of Science & Technology
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.
Maxim Pharmaceuticals
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Texas A&M University
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.
Abbott
Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.
Senju Pharmaceutical
Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against ?-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble A? peptide formation.
Ewha Womans University
Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors.
Abbott
1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors.
Cephalon
Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus.
The University of Tennessee Health Science Center
Potent peptide alpha-ketohydroxamate inhibitors of recombinant human calpain I.
Cephalon
Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors.
Knoll
Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.
Abbvie Deutschland
Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases.
Georgia Institute of Technology
Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain.
Alkermes
C1 and N5 derivatives of cerpegin: synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome.
Yerevan State University
Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold.
Universidad De Alcal£
Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1' Extension.
Abbvie Deutschland
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.
Abbvie Deutschland