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Article Title

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Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.

Northwestern University

2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.

Northwestern University

Cell-permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders.

Vibrant Pharma

Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Structure-based design of bacterial nitric oxide synthase inhibitors.

University of California

Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.

Northwestern University

Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.

Northwestern University

Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.

Northwestern University

Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.

Northwestern University

An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.

Northwestern University

Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.

Northwestern University

In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.

Northwestern University

Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.

Northwestern University

Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.

University of California

Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase.

Universit£

Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).

Neuraxon

Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.

Christian-Albrechts-University of Kiel

Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.

Neuraxon

Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.

Queen'S University

Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.

Northwestern University

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.

Northwestern University

Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.

Institut Henri Beaufour

1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.

Northwestern University

Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.

Northwestern University

3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.

Neuraxon

Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.

Neuraxon

Novel inhibitors of nitric oxide synthase with antioxidant properties.

Universit£

Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

Neuraxon

Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.

Northwestern University

Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents.

North-West University

Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Synthesis and biological evaluation of indazole derivatives.

Uned

Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.

Northwestern University

N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.

Università

Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.

Northwestern University

Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

Northwestern University

2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.

University of Pennsylvania

Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.

Northwestern University

Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.

Institute of Marine Science

 

Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

TBA

 

1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine

TBA

L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.

Northwestern University

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.

Northwestern University

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.

Northwestern University

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

Université

4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.

Upres-Ea 3915

Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.

Northwestern University

Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.

Northwestern University

2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.

Northwestern University

Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.

Pfizer

Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.

Universidad De Granada

Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.

Université

Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.

Astrazeneca R&D Charnwood

3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.

Astrazeneca R&D Charnwood

Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.

Wake Forest University

Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.

Wake Forest University Winston-Salem

Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.

Northwestern University

A new class of selective and potent inhibitors of neuronal nitric oxide synthase.

Pfizer

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.

Northwestern University

Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.

Abbott Laboratories

Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Northwestern University

Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.

University of Chieti "G. D'Annunzio

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Northwestern University

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Northwestern University

Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.

Northwestern University

2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.

Sun Yat-Sen University

Identification and characterization of novel somatostatin antagonists.

Cyenamid Agricultural Research Center

Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist.

Parke-Davis Pharmaceutical Research

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.

Portland State University

Covalent reactions of wortmannin under physiological conditions.

Massachusetts General Hospital

Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.

Emory University