PMID

Data

Article Title

Organization

Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.

Cambridge University Forvie Site

2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.

Smithkline Beecham

 

The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists

TBA

 

The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design

TBA

Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.

F. Hoffmann-La Roche

 

Identification and chemical synthesis of MDL 105,212, a non-peptide tachykinin antagonist with high affinity for NK₁ and NK₂ receptors

TBA

 

The design and synthesis of non-peptide ligands with affinity and selectivity for tachykinin receptors

TBA

 

Alternative strategies towards the identification of chemical lead compounds by rational design

TBA

 

Methionine replacements in biologically active peptides

TBA

Combined tachykinin receptor antagonist: synthesis and stereochemical structure-activity relationships of novel morpholine analogues.

Sankyo

New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists.

Glaxo Wellcome Medicines Research Centre

Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.

Hebrew University of Jerusalem

The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst.

Pfizer