PMID

Data

Article Title

Organization

a-Conotoxin [S9A]TxID Potently Discriminates betweena3ß4 anda6/a3ß4 Nicotinic Acetylcholine Receptors.

Hainan University

Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors.

Hainan University

Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.

Ohio University

Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.

University of Kentucky

 

2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands

TBA

Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.

University of Utah

Mechanism of Action and Structure-Activity Relationship of ?-Conotoxin Mr1.1 at the Human ?9?10 Nicotinic Acetylcholine Receptor.

Ocean University of China

From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human ?9?10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.

Universit£

Miniproteins in medicinal chemistry.

Wroclaw University of Science and Technology

Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human ?7 Nicotinic Acetylcholine Receptors.

Hainan University

Discovery of Methylene Thioacetal-Incorporated ?-RgIA Analogues as Potent and Stable Antagonists of the Human ?9?10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.

University of Utah

Computational and Functional Mapping of Human and Rat ?6?4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs.

Veterans Affairs Medical Center

Targeting of N-Type Calcium Channels via GABA

Beijing Institute of Biotechnology

Development of Conformationally Constrained ?-RgIA Analogues as Stable Peptide Antagonists of Human ?9?10 Nicotinic Acetylcholine Receptors.

University of Utah

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.

Abbott Laboratories

Structure and Activity Studies of Disulfide-Deficient Analogues of ?O-Conotoxin GeXIVA.

Hainan University

PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets ?3?2 Nicotinic Acetylcholine Receptors.

Veterans Affairs Medical Center

Dimerization of ?-Conotoxins as a Strategy to Enhance the Inhibition of the Human ?7 and ?9?10 Nicotinic Acetylcholine Receptors.

Ocean University of China

Determination of the ?-conotoxin Vc1.1 binding site on the ?9?10 nicotinic acetylcholine receptor.

The University of Queensland

Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ?7-nAChR, ?9-nAChR Antagonist and of a Pro-Oxidant Mitocan.

Universit£

Molecular Determinants Conferring the Stoichiometric-Dependent Activity of ?-Conotoxins at the Human ?9?10 Nicotinic Acetylcholine Receptor Subtype.

Ocean University of China

Single Amino Acid Substitution in ?-Conotoxin TxID Reveals a Specific ?3?4 Nicotinic Acetylcholine Receptor Antagonist.

Hainan University